Always carry water with you and stop regularly to see if your cat needs a drink, particularly in hot weather.
It is preferable the first few times it goes for a trip in a vehicle to have eaten nothing beforehand as food can sometimes make cats feel sick.
If the cat seems calm then it is possible to let it out of the cage provided it sits quietly on a seat.
Don't leave any windows open where it might be able to get out and particularly when you stop the vehicle make sure it doesn't jump out the door and go somewhere where it could be endangered.
If you do have windows down make sure there are no drafts that could be affecting your cat and don't let it sit up in the back window of vehicles in direct sunlight where it might get overheated and become ill.
Generally if the cat has been in a vehicle as a kitten it won't mind travel all that much and it will generally only become frightened if it associates travel with some unpleasant event.
Cats can find comfort in having a favorite blanket or bed in the vehicle with them and also a comforting hand from the owner beside them.
Consider their feelings and treat them as you would a young child and you shouldn't have too many problems.
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